ASPE focuses on many areas of interests that are important in the research, design, development, manufacture and measurement of high accuracy components and systems. These areas are as follows:

The precision engineering toolbox includes design methodology, uncertainty analysis (error budgeting), metrology, calibration/error compensation, precision controls and actuators/sensors. ASPE's enabling technologies include but are not limited to the following industries: microelectronics, automotive, optics and photonics, MEMS, nanotechnology, defense and machine tools.

ASPE members represent a variety of technical areas - from engineering (mechanical, electrical, optical and industrial) to materials science, physics, chemistry, mathematics and computer science - and are employed in industry, academia and national labs.